Drug Info
- Brand Name: Addyi
- Active Ingredient: Flibanserin
- Manufacturer: Sprout Pharmaceuticals, Inc.
Active substance Flibanserin
Flibanserin modulates central neurotransmission as a 5-HT₁A receptor agonist and 5-HT₂A receptor antagonist, with downstream effects that can increase dopamine and norepinephrine signaling while normalizing serotonin tone in brain circuits related to sexual desire. It is not a hormonal therapy and is not an on-demand medicine.
After oral dosing, flibanserin reaches peak plasma levels in a few hours; the terminal half-life supports once-daily administration. Bedtime dosing reduces the risk of hypotension, syncope, and CNS effects (dizziness, somnolence). Flibanserin is metabolized mainly via CYP3A4 (and to a lesser extent CYP2C19). Co-administration with strong or moderate CYP3A4 inhibitors can markedly increase exposure and the risk of adverse effects; hepatic impairment also raises exposure and is a contraindication.
Indications for use
- Acquired, generalized HSDD in premenopausal women, when symptoms cause significant distress and other causes have been ruled out
- Not indicated for postmenopausal women, men, or to enhance sexual performance
Use is determined by the prescriber according to local labeling and individual assessment.
Treatment regimens and dosages
Use Addyi exactly as prescribed.
- Recommended dose: 100 mg once daily at bedtime.
- Evaluation of benefit: if no improvement in sexual desire and related distress is observed after 8 weeks, discontinue treatment.
- Administration: swallow the tablet whole with water at bedtime.
- Alcohol: avoid alcohol; combining with Addyi increases the risk of severe hypotension and syncope. If alcohol was consumed that evening, skip the dose.
- Driving/alert tasks: do not drive or perform hazardous activities until at least 6 hours after taking Addyi (bedtime dosing helps meet this window).
Dose adjustments are not used beyond start/stop decisions; therapy is either continued at 100 mg nightly if effective and well-tolerated or discontinued.
Recommendations for use
Maintain a regular bedtime schedule. Prioritize adequate sleep—fatigue can suppress desire and amplify dizziness. Limit or avoid sedatives and alcohol. Keep a short weekly log (desire, distress about low desire, adverse effects, sleep quality); this helps your clinician judge benefit at the 4–8-week review. If daytime lightheadedness occurs, rise slowly from sitting, hydrate well, and discuss whether other medicines (e.g., antihypertensives, sleep aids) may be contributing.
Missed Dose
If you miss a bedtime dose, do not take it the next morning. Take one tablet at the next bedtime only. Do not double doses.
Precautions
- Absolute contraindications:
- Hepatic impairment (any degree)
- Concomitant strong or moderate CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin/erythromycin, ritonavir/cobicistat, nefazodone, fluconazole)
- Alcohol: increases risk of hypotension/syncope—avoid use.
- Hypotension/syncope: greater risk with dehydration, heat exposure, illness, or antihypertensives; take at bedtime and rise slowly the next morning.
- CNS depression: dizziness, somnolence, fatigue; avoid hazardous tasks ≤6 hours post-dose.
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John’s wort) may reduce effectiveness.
- Pregnancy/lactation: see below—treatment decisions are individualized.
- Not for men or postmenopausal women.
Use during pregnancy
Addyi is not intended for use during pregnancy. If you become pregnant, inform your clinician to discuss discontinuation. For breastfeeding, decisions are individualized; discuss potential infant exposure and alternatives.
Possible side effects
- Common: dizziness, somnolence, nausea, fatigue, insomnia, dry mouth.
- Less common: hypotension, syncope (especially with alcohol or interacting drugs), anxiety, abdominal discomfort.
- Serious—seek medical attention: fainting or near-fainting, severe dizziness, palpitations, allergic reaction (facial swelling, wheeze, rash).
Record timing relative to the dose, alcohol, and other medicines; this helps clinicians decide on continuation or changes to the overall plan.
Flibanserin: interaction with other drugs
- Strong/moderate CYP3A4 inhibitors: contraindicated (marked exposure increase and hypotension/syncope risk).
- CYP3A4 inducers: may lower efficacy (rifampin, carbamazepine, phenytoin, St. John’s wort).
- CYP2C19 inhibitors / poor metabolizers: higher exposure possible—clinician monitoring advised.
- CNS depressants (benzodiazepines, opioids, sedating antihistamines), sleep aids, alcohol: additive sedation/hypotension—avoid or use only with medical guidance.
- Grapefruit/grapefruit juice: can inhibit CYP3A4 and raise levels—avoid.
Always provide a complete, up-to-date list of prescription/OTC medicines, vitamins, and herbal supplements.
Analogs & Generics
Same active ingredient (flibanserin — international examples)
- Flibanserin tablets (various manufacturers) — 100 mg, once nightly
Drug analogs (different active ingredient, same purpose — HSDD therapy)
- Vyleesi (bremelanotide) — on-demand subcutaneous injection for premenopausal HSDD (different mechanism)
- Selected non-pharmacologic approaches often used alongside medication (sex therapy, CBT, sleep/stress optimization) per clinician judgment
Storage
Store at 15–25°C in a dry place away from direct heat and sunlight. Keep tablets in the original packaging and out of the reach of children. Do not use after the expiry date printed on the pack.
Customer Experience – What to Expect
Many patients note gradual changes over 4–8 weeks: increased spontaneous interest in intimacy, fewer distressing thoughts about low desire, and a greater sense of responsiveness. Early on, some experience dizziness or sleepiness, especially if hydration is low or bedtime is irregular; these effects often ease with stable routines and strict avoidance of alcohol. Keeping a brief weekly diary of desire, distress, sleep, and any side effects helps you and your clinician confirm benefit and decide whether to continue.
FAQ
Who is Addyi for?
Premenopausal women with acquired, generalized HSDD causing significant distress—after other causes are ruled out.
How long until it works?
Improvements are typically assessed at 8 weeks. If there is no meaningful benefit by then, your clinician may advise stopping.
Can I drink alcohol while taking Addyi?
Avoid alcohol; the combination increases the risk of severe low blood pressure and fainting. If alcohol was consumed, skip the dose that night.
Can I drive the next morning?
Do not drive or perform hazardous tasks for at least 6 hours after taking Addyi. Bedtime dosing helps meet this interval.
Is Addyi a hormonal treatment?
No. It acts on central neurotransmitters (serotonin, dopamine, norepinephrine), not on sex hormones.
Can men take Addyi?
No. Addyi is not indicated for men or for postmenopausal women.
The best offer for Addyi online on the market
Right now you can buy Addyi in our online pharmacy. If you are looking for the best place to order Addyi or other medicines containing flibanserin for HSDD, then you have come to the right place.
Advantages of our pharmacy:
- Confidentiality. Most people prefer to keep intimate health matters private. By ordering Addyi online, you avoid unnecessary face-to-face discussions.
- Price. Buying Addyi online is more beneficial than purchasing at a clinic or local pharmacy.
- Quantity. Doctors often issue a prescription for one or two packs. Our pharmacy allows you to buy the required number of Addyi packs to ensure an adequate supply.
- Convenience. You make a purchase at a convenient time for you, without sacrificing service or security. You do not need to make an appointment or visit a clinic.
- Information. On our website, you can find details on dosage, side effects, safe use, and other information necessary for treatment.
We work hard to provide the best possible customer service and to ensure that our medications help restore healthy, comfortable sexual desire under medical supervision.
